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Just an Allergy or Could It Be Systemic Mastocytosis?

Understanding Systemic Mastocytosis

This activity is for people who want to learn more about systemic mastocytosis (SM). The goal is to help you understand SM and its possible symptoms.

You will learn about:

  • SM and its symptoms

  • Types of SM

  • Causes and risk factors for SM

  • SM and your immune system

  • Complications that may happen with SM

Test Your Knowledge

Systemic Mastocytosis

Systemic mastocytosis is a rare health condition where you have too many mast cells, a type of white blood cell. Mast cells are part of your immune system and, once activated, they release mediators -- such as histamine -- that cause certain immune responses.

With SM, extra mast cells can build up in your tissues and organs and cause an increased immune response. This can lead to symptoms and additional problems (complications).

Learn about SM and how it can affect the body.

Test Your Knowledge

Survey questions


You have successfully completed the program Just an Allergy or Could It Be Systemic Mastocytosis?

View Additional Materials on this topic that you may find useful:

Systemic Mastocytosis

Systemic Mastocytosis -- National Library of Medicine

Systemic Mastocytosis -- Getting a Diagnosis

Living With SM

The Mast Cell Disease Society (TMS) -- Finding Support

Authors and Disclosures

Clinician Reviewer

Karen Badal, MD, MPH

Senior Medical Education Director, Medscape, LLC. Karen Badal, MD, MPH, has no relevant financial relationships.


Anita A. Galdieri, PharmD, RPh

Associate Director, Content Development, Medscape, LLC. Anita A. Galdieri, PharmD, RPh, has no relevant financial relationships.


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